Liquid gel injected directly into solid tumors not only solves the problem of rapid distribution of immunotherapy drugs but also provides visual confirmation of their targeted delivery. The multifunctional gel, called Imigel, contains the immunostimulating drug imiquimod, approved by the US Food and Drug Administration, and has a copolymer structure that provides controlled release of the drug.
In mouse models of commonly resistant colon and breast cancers, the gel combined with checkpoint inhibitor therapy led to significant improvements in survival, resulting in complete regression of both treated and resected tumors.
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Source: Ferra
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