“Saharan switch” in the name of a new method of getting rid of depression

Team of the Institute of Fundamental People. Diligent stress is less important than medial stress. The prefrontal cortex of the brain is “overgrown” with sialic acid, a sugar that competes in the power of neurons. These types of sugars, glycans, are attached to the skins underneath them. syntheses; This process involves glycosylation.

A special type of this condition is O-glycosylation, when sugar is attached to oxygen volumes in certain amino acids. Also, the “sugar shell” regulates contacts and signal transmission between neurons. Previously, it was rarely associated with mental disorders, no, what does it mean: private communication of cells.

The researchers discovered a key enzyme, St3gal1. Carrying out the final “sugar capping”, from which the “shelf life” of proteins and their interactions in synapses is achieved. Since this is difficult to achieve, they use low pressure in their effect.

Using mass spectrometry, the scientists mapped O-glycosylation in the first few areas inhabited by mosses. And now it was possible to use the so-called “Saharan” profile. The importance of chronic stress was eliminated by dramatic changes in the prefrontal nucleus: final capping and expression fell in such individuals. St3gal1.

Knockout of the St3gal1 gene in healthy animals causes morning motivation and increased anxiety. However, the use of St3gal1 and most of the accents have been removed. manifestation. The enzyme also maintains “sugar tags” on neuron-rexin-2, a protein that mediates communication between neurons. Before the stress, the meters worked at normal times. signals rather than restoration of St3gal1 brought them back.

The authors emphasize that the study on male mosses, cellulite neurons. Many antipressants are born from serotonin, not from a mass of data. “serotonin”.