A preventive treatment for Alzheimer’s disease (AD), described in a recent study led by researchers at the University of Milan, Italy, promises to be well received by its target audience. According to scientists, some chemical compounds derived from hop flowers Beer as a nutraceutical food with unique health benefits🇧🇷
The most common form of neurodegenerative dementia in the elderly, AD is a disease that causes memory loss and personality changes🇧🇷 One of the biggest challenges in treatment is the time interval between the onset of degenerative biochemical processes and the onset of symptoms.
Hence the need to develop effective prophylactic and therapeutic strategies. In this sense, the search for natural compounds that can integrate a preventive diet of the biochemical mechanisms responsible for the emergence of AD has guided this work. hops used in beers was chosen as the research object.
The search for the best hops to prevent Alzheimer’s
To validate their hypothesis, the researchers characterized four hop cultivars. – Cascade, Saaz, Tettnang and Summit – It is also used in the brewing process. Tests showed that some extracts have antioxidant properties that can prevent the concentration of beta amyloid proteins in human nerve cells.
Used in many types of beer and in lighter beers, Tettnang was considered the most promising hop. By dissecting this extract, the researchers identified a strain containing high levels of polyphenols, with stronger antibiotic and anti-aggregation activity than the others. These molecules also facilitate processes that lead the body to eliminate so-called misfolded neurotoxic proteins (the properties of Alzheimer’s).
To evaluate this protective effect, the researchers successfully tested it. In vivo antiamyloidogenic activity of hops in worms of the transgenic strain C. elegans🇧🇷 So, hop compounds could be the basis of nutraceuticals to prevent Alzheimer’s disease.
ARTICLE 🇧🇷 ACS Chemical Neuroscience – DOI: 10.1021/acschemneuro.2c00444.
Source: Tec Mundo
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