A new biomaterial made from body tissues that can be injected intravenously It was recently developed by researchers at the University of California at San Diego in the United States. Intravascular grafting of this extracellular matrix, tested in rodents and other large animal models, has proven effective in treating tissue damage caused by heart attacks.
The new material, made from decellularized, enzymatically digested and fractionated ventricular myocardium, “allows you to treat damaged tissue from the inside out,” as well as being applicable immediately after a heart attack, he explains. work, Karen Christman of UC San Diego. “This is a new approach to regenerative engineering,” praises the bioengineering professor.
Evaluating the safety and efficacy of biomaterials in humans could begin in a year or two, Christman says, and could benefit large numbers of injured people. growing with 785,000 new heart attack cases each year Only we.
How was the new injectable extracellular matrix created?
A heart attack patient soon develops scar tissue that reduces muscle function and leads to dangerous congestive heart failure. that means the heart stops pumping enough blood to meet the body’s needs.
The previous solution, developed by the same team as the current study, was a hydrogel made from a natural support of heart muscle tissue: the extracellular matrix. The problem is that because of its consistency material, can only be injected directly into the heart muscle. However, doctors had to wait a week after the infarction, as the injection of the needle could cause further tissue damage.
To circumvent this limitation, the paper’s first author, Martin Spang, a doctoral student in Chrstiman’s lab, decided to place the hydrogel in a centrifuge, sieving the larger particles and keeping only the nanometric ones. Not only did the material pass through blood vessels and spaces between endothelial cells into tissue, but to everyone’s surprise, binds to them, closing the gaps and accelerating vascular healing.
ARTICLE – Doga Biomedical Engineering – DOI: 10.1038/s41551-022-00964-5.
Source: Tec Mundo
I’m Blaine Morgan, an experienced journalist and writer with over 8 years of experience in the tech industry. My expertise lies in writing about technology news and trends, covering everything from cutting-edge gadgets to emerging software developments. I’ve written for several leading publications including Gadget Onus where I am an author.
