Modern methods of donor selection have significantly increased the chances of recovery of patients after bone marrow transplantation. This is according to the director of the Center’s Institute of Hematology, Immunology and Cell Technologies. Dima Rogachev, Alexey Maschan.

Today, bone marrow transplantation can help many different diseases such as malignant blood diseases, innate immune system and metabolic disorders. Before the beginning of the 21st century, the probability of recovery of patients after transplantation from unrelated donors was only 20-30%, but modern technologies have doubled these figures.

This progress is due to the use of new methods of donor selection, more effective clearance of the bone marrow from cells that could cause complications, and the expansion of potential donor databases. Today, the selection of the appropriate donor is carried out using DNA typing, in which the genes responsible for histocompatibility are compared. Immunosuppression is performed after transplantation to reduce the risk of organ rejection.

Thanks to advances in the selection system based on DNA typing, the results of transplants from related and unrelated donors are almost the same today. This significantly increased the chances of recovery after a bone marrow transplant.

Source: Ferra

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