By analyzing mice that developed serrated polyps and tumors, the study uncovered the chain of molecular events that led to increased cholesterol production. Confirming their findings in humans, the researchers showed that blocking cholesterol production in mouse models prevented the progression of these specific intestinal tumors.
The study’s potential impact extends to clinical trials, where cholesterol-lowering interventions could revolutionize prevention strategies for this highly aggressive type of cancer.
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Source: Ferra
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