A research team led by Ashley Brown and including Andrew Lyon of Chapman University has addressed a critical gap in the treatment of uncontrolled bleeding. Conventional platelet transfusions, which are often required in trauma patients, have limitations. Synthetic PLPs offer a promising alternative.
These engineered particles mimic natural platelets. They travel through the bloodstream, reaching sites of injury and helping blood clot. They also support wound healing.
Extensive testing in large animal models has demonstrated the effectiveness and safety of PLP in a variety of scenarios. They were well tolerated and showed recovery rates comparable to conventional platelet transfusions. Another important finding was a unique elimination pathway of the particles; They were excreted through the kidneys. This offers a significant safety advantage over other injectable biomaterials.
The positive results laid the foundation for further developments, with the ultimate goal of use in humans.
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Source: Ferra
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