So far, it has been difficult to examine these proteins – it is difficult to distinguish them from cells suitable for analysis, and experiments require expensive equipment. However, scientists from Russia, the United States and Brazil have discovered the thermal shift method (TSA), which was previously used to evaluate the stability of proteins.

This method monitors how protein behavior changes when heated and interacts with other substances. Scientists have developed three mathematical models that allow you to evaluate how much a particular drug is related to the receptor.

Methodology was controlled on proteins associated with cardiovascular diseases and asthma and received encouraging results.

Source: Ferra

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