The fight against opioid addiction in the US reaches a new level – a study in Houston has developed an experimental vaccine against fentanyl. The insidiousness of this drug with a high probability of residing after fentanyl addiction therapy. The will and desire of a person are powerless here, but they are investigated as owners from the action of this substance.
Vaccine-based hapten compounds whose molecules meet with fentanyl. The hapten assembled with the CRM197 carrier protein to run the antibody production process on behalf of the client. They look for molecules of both hapten and fentanyl in the bloodstream, and bind to the images, blocking their movement. Thus, narcotic immunity to the brain, a person does not experience euphoria and the reversibility of dependence does not occur.
The vaccine was further boosted with a dmLT adjuvant derived from E. coli bacteria. This is a survey to get an immune response and improve the effectiveness of the vaccine. The result is a highly targeted substance that does not respond to other types of opioids. Therefore, a patient with a fentanyl vaccine can be safely given, for example, morphine as an inoculation.
Experiments on rats showed exactly the result that the counters were counting on – after vaccination, the rodents became indifferent to fentanyl, which primarily caused them a narcotic effect. Now the authors of the vaccine are urging the regulator to approve the start of human experiments with fentan as soon as possible. addiction.
Source: Tech Cult
