The authors from the University of Alberta analyzed data collected from 623 older adults over the age of 44. In particular, they were concerned with two risk factors for Alzheimer’s disease – the presence of mutations in the BIN1 gene and vascular health.
It turned out that the poor state of the vessels, that is, high pulse pressure, is associated with the deterioration of episodic memory in men and women. However, even with a good pulse pressure, the risk of disease was high if there was a mutation in BIN1. And the presence of these two factors had a much stronger effect on memory in men.