The majority of participants (87%) had at least one psychiatric disorder, including attention deficit hyperactivity disorder (ADHD), anxiety, depression, or autism spectrum disorder.
The risk of self-harm was five times higher among girls than boys. The study compared self-harm caused by the same person while taking melatonin and not taking it, taking into account factors such as genetic predisposition and sleep disturbance.
The results showed a marked increase in the risk of self-harm shortly before starting melatonin, followed by a 50% decrease in the months that followed. This correlation was most pronounced among adolescent girls with depression or anxiety disorders.
While the study did not establish a causal relationship between melatonin and reduced self-harm, the evidence remains consistent even when explaining the use of other medications, such as antidepressants.
Source: Ferra
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