The researchers used nematodes, an invertebrate model organism. caenorhabditis elegansand cultured human cells. They carried genes for two neurodegenerative diseases that usually occur in old age: amyotrophic lateral sclerosis (ALS) and Huntington’s disease. Both diseases are characterized by the accumulation of harmful protein deposits.
In both model organisms, cold actively removed protein deposits and thus prevented the development of both ALS and Huntington’s disease. This was achieved with a moderate drop in temperature.
In addition, it turns out that protein deposits can be removed using genetic overexpression of the activator. Thus, it is possible to reduce the risk of disease even at normal body temperature.
Source: Ferra
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