Fashion influences clothing, music and even medicines. The latter may seem crazy, but it is reality. 2024, for example, became the year Ozempic. This is a drug intended to treat type 2 diabetes. However, as soon as someone mentioned on TikTok that weight loss This is one of its side effects: thousands of people flocked to pharmacies. In some countries there was even shortage which is dangerous for diabetics. Therefore, the discovery of A. natural substitute for Ozempic This is very promising news.
This was reported by a group of scientists from Jiangnan University, from China. His research, recently published in Natural microbiologybased on usage metabolite produced by a bacterium gut microbiota to achieve exactly the same effect as Ozempic.
These effects consist mainly of reducing appetite, especially sugar cravings, and regulating blood glucose levels. Its natural substitute, Ozempica, is currently being tested in mice, but is expected to be useful in humans if other studies are taken into account. Let’s see how it works then.
How does semaglutide work?
Ozempic is actually a commercial name semaglutide. This drug is glucagon-like peptide 1 (GLP-1) analoguea hormone that is released in response to food intake to regulate feeling of satiety and blood glucose levels. Essentially, this is one of the strategies our body follows to tell us that we have eaten enough. The release of many hormones is triggered, one of which is GLP-1. It has been observed that people with type 2 diabetes have impaired mechanisms for releasing this hormone. Therefore, it is more difficult for them to control satiety, and their blood glucose levels may experience dangerous spikes.
To treat this problem it is prescribed semaglutide injectionsa synthetic analogue of GLP that binds to the same receptors and mimics its function when it is lacking. We have already seen the effect this medicine has on diabetics. But what does a natural substitute for Ozempic do then?
Bacterial metabolite as a natural substitute for Ozempic.
Many studies conducted over the years have shown that the composition of the microbiota largely depends on ability to control appetite and satiety. Most of these processes are controlled by hormones released by the brain, but there appear to be triggers in the gut.
To clarify these processes, the authors of the just published study analyzed the consequences of deficiencies of various intestinal proteins in mice. Thus, they saw that if rodents were unable to synthesize a protein called Ffar4 colonies of bacteria called Bacteroides vulgaris they were cut. As a result, levels of a hormone known as FGF21, whose function is related to control craving for sweets.
Previous studies, also conducted in mice, have shown that administration of GLP-1 analogues, such as Ozempic, stimulates Production FGF21. And what will be the consequences for people? Another previous study found several variants in the gene encoding FGF21 synthesis, and they appear to be associated with excessive sugar consumption. In addition, there are Ffar4 mutations that also lead to decreased FGF21 synthesis. Thus, if all the pieces are put together, it turns out that there is a connection between the presence Bacteroides vulgaris in the intestines and control sugar cravings.
Bacteria secrete metabolites that stimulate the synthesis of FGF21, as well as Ffar4. In turn, this hormone, which is also mediated by GLP-1, helps control satiety and sugar cravings.
Taking all this into account, the authors of the latest study suggested that bacteria may function as natural substitute for Ozempic. Specifically, they took one of its metabolites and injected it laboratory mice. So they saw that GLP-1 levels increased, along with FGF21 levels, and finally food cravings decreased. This, as a result, helps control blood glucose levels and, in turn, reduce weight.
It is more than obvious that uncontrolled use of Ozempic can be dangerous. It could also cause even more dangerous shortages among those who really need the drug. Therefore, a probiotic that works as a natural substitute for Ozempic may be a great alternative. We will continue to closely monitor developments in this area of research.
Source: Hiper Textual
