The race to the first male contraceptives is not freed from criticism. There are many people who think that if the same doubts were devoted to allowing Women’s tabletToday there would be no contraceptives. In the same way, many people believe that all the necessary efforts are not directed, because There are female contraceptives And why share the weight of contraception? Despite all this, every time a male ending Clinical trials in people This is celebrated with joy. The last one who has reached this YCT-529The medicine, which, in the visible, has overcome 1 phase of clinical trials after showing great effectiveness in mice.
Does this mean that we can leave the bells in flight? Unfortunately no. Phase 1 clinical trials in public only serves to demonstrate that at wide moves this is a safe connection for people. It is still possible to check its effectiveness and, by the way, continue training with samples of larger participants, which are its side effects.
Some media talk about 99% efficiency in people. However, this effectiveness was measured in mice. Clinical trials in people of this male contraceptive are still in diapers. This is good news that at least reached them, but we must see it out of caution.
How does this men’s contraceptive work?
A Vitamin a This is important for spermatogenesis. Recall that, unlike what is happening with female gametes, whose reservation is ready from birth, sperm is continuously made from puberty. This process requires good levels of vitamin A, therefore, if it is unavailable, it can temporarily stop. Therefore, many years ago a research route appeared, which explores Blocking the receptor This vitamin as a reversible male contraceptive.
One of the molecules that were used to inhibit these receptors is only the YCT-529. There are currently published results of use Both in non -human primates and mice. In the latter, very promising results were obtained. After 4 weeks of oral introduction The formation of spermatozoa in rodents was suppressed, but this returned to normal condition after 6 weeks Without the administration of the drug. They did not leave pregnant most women with whom they kindled, and there were hardly side effects. The effectiveness was designed by 99%.
In the case of non -human primates, similar results were obtained, although there were enough of them 2 weeks for spermatogenesis And they were necessary for up to 15 weeks to have a normal number of sperm. It was clear that he was a good candidate for a male contraceptive.
What about people?
The greatest advantage of the YCT-529 as a male contraceptive is that it is reversible and not Hormornal. Options for contraceptives for men based on Hormonal introductionSome profiles came to move a lot in clinical trials. However, in the end, he rejected his use from the detection of side effects. It is true that there was one whose progress was automatically blocked when a rather high level Impact on moodThis in one of the cases they even led to suicide. Nevertheless, other clinical trials were carried out for a male contraceptive, which did not finish the arrival of the drug to the market from the detection of side effects, such as acne. If female contraceptives were not sold from acne, they were not.
In any case, in the end it was decided to concentrate the development of male contraceptives on drugs that are not based on hormones. Some are injected, for example gel that blocks torn off It is reversible so that sperm could not go through them. Others, such as YCT-529, directly attack sperm synthesis. And it seems that this is a good option. At least in laboratory animals. But we cannot leave the bells on the fly.
It’s time to continue to wait for the arrival of a male contraceptive
It has not yet been increased in clinical trials in people enough to determine its effectiveness in our type. Volunteers are gaining, so we may not be late for new information.
Meanwhile, there are other contraceptives that advanced to such an extent that their developers launched the release date. Last DMAU, The injection drug, which also acts on spermatogenesis and gave very good results at the first stage of clinical trials in 2019. Scientists who developed it said that they could be ready in 10 years. 4 years after this date, clinical trials that began later remain unknown. The best will not trust us. It seems that the race is progressing, but, as a woman won for obvious reasons, it does not seem that there are many hasty ones with male contraceptives to achieve the goal.
Source: Hiper Textual
