When the heart stops beating, the organs swell, constricting the blood vessels and blocking circulation. In turn, a sharp cessation of the supply of oxygen and nutrients leads to deterioration and cell deaththat have run out of fuel. Thus, the organs quickly stop working. It is for this reason that it is necessary to act very quickly in order to carry out a transplant in which donor – deceased person. But what if this degeneration of cells after death could be prevented or at least delayed? This suggestion, almost typical of a Mary Shelley novel, was made by a group of scholars from Yale university. And best of all, in a sense, they succeeded in giving some of the life back to the organs of the dead pigs.
These researchers have already made all sorts of headlines in 2019 when they managed to restore blood circulation and some cellular functions in the brains of dead pigs. Naturally, the news was exaggerated and people started talking about the resurrection of the dead. It was not what they did, but still it was a great discovery, which they now went much further, repeating their feat in the rest of the organs of these animals.
This is stated in a study published today in Nature. It describes both the mechanism they followed and the results. Some were within expectations, but others they were pleasantly surprised. And the fact that they managed to restore even some functions that they had not even suspected before.
Restoration of cells of dead pigs
In 2019, these Yale scientists achieved restore some functions of the brain cells of dead pigs thanks to the infusion of A. experimental liquid. This included a cocktail of everything necessary to restore the functions lost after death. FROM anticoagulants before cytoprotectorspassing through other substances such as hemoglobin, which is involved in the transport of oxygen in cells. In addition, it contains some compounds that help suppress an intense inflammatory response which is also involved in the destruction of cells after death.
With this connection they called BrainEx, the unimaginable has been achieved. This was particularly interesting as the brain is an organ highly susceptible to cellular stress caused by insufficient blood supply, called ischemia. If they could with him, then why not with the rest of the body?
Over these three years, they developed this idea, giving shape to the study that is presented today. It describes how his work with OrganExan improved version of the fluid they only used for the brain.
First, it caused heart attack pigs under anesthesia. The animals were then hooked up to a machine that mimics the effects of already stopped lungs and hearts. It looks like cars ECMO used in patients awaiting transplantation. After the completion of the process, six hours passed, after which its incredible effects were confirmed.
much more than expected
The brain effects of the dead pigs were similar to those of 2019. That is, the function of some of its cells was restored, but there was no electrical activity that could indicate consciousness.
On the other hand, many important cellular functions that would have already been lost without treatment remain intact. Even some organs such as kidneys, liver and heart they restored some of their functionality.
What they saw in the latter was especially interesting, as there was evidence electrical activity and still kept ability to enter into a contract. In addition, blood circulation was restored absolutely throughout the body. Was even involuntary muscle movements at the level of the head and neck!
In short, if they tried to microscopically examine cells from a healthy organ and cells from the same organ treated with OrganEx, there were practically no differences.
What is all this for?
As in 2019, it is important to note that the intention of these scientists is not to raise the dead.
But they can help prevent a large number of deaths. And thanks to OrganEx you can significantly increase the lifespan of organs before transplant. Now they have done it with dead pigs, but they intend to extrapolate this to humans in the future.
In addition, as explained in the statement, they believe that all this “could help in the treatment of organs or tissues damaged by ischemia during heart attacks or strokes“. The range of possibilities is huge, although there is still a lot of work ahead. Bringing the dead back to life is still far beyond the reach of science, but it seemed almost as unattainable a few years ago, and now we see that it is possible. Reality, by virtue of being reality, will always be much more exciting than fiction.
Source: Hiper Textual
