Clue? The elusive Christchurch mutation in the APOE gene has also been found in genetically modified mice. The discovery suggests it could break the link between early amyloid deposition and subsequent cognitive decline.
The mutation activates microglia, the brain’s cleansing team, effectively neutralizing tau pathology and halting neurodegeneration. Now a promising possibility opens up: Can we mimic this immunity to render amyloid deposition harmless?
As the clock ticks on a disease that has been evolving for more than 30 years, this discovery offers hope to millions of people and marks a sign of progress in the quest to unravel the mysteries of Alzheimer’s disease.
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Source: Ferra
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