This notorious superbug lives in hospitals and infects debilitated patients with pneumonia and sepsis. Its resistance to current antibiotics ranks it high on the WHO list of “critical pathogens”, along with challenging bacteria such as Pseudomonas aeruginosa and Enterobacteriaceae.
But zozurabalpin proves the opposite. In mouse models, this wonder drug effectively killed the crabs.
The key to Zosurabalpin’s success lies in its unique mode of action. Unlike traditional antibiotics that target the inner surface of bacteria, Zosurabalpin activates the mechanism responsible for creating the tough outer surface of the crabs. This shell, strengthened by the lipopolysaccharide (LPS) molecule, acts as a shield, repelling antibiotics and interfering with the functioning of our immune system. Zosurabalpin disrupts the transport of LPS to the shell, leaving the bacteria vulnerable.
“This is the first molecule with a new mechanism of action against Gram-negative bacteria in the last 50 years,” exclaims Professor Daniel Kane of Harvard University, the project’s principal investigator. “This is a significant breakthrough in our fight against antibiotic resistance.”
There is still a long way to go from the laboratory to the hospitals, and trials are currently being conducted on humans. But success in mice offers a strong glimmer of hope in the ongoing fight against the silent epidemic of antibiotic resistance.
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Source: Ferra
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