The researchers fed mice a variety of high-fat diets (40% of calories from fat) for 24 weeks and analyzed not only changes in the gut but also gene expression in the gut. All three diets, including diets high in saturated, monounsaturated and polyunsaturated fats, caused alarming changes in gene activity.
Increase in the number of harmful E. coli, suppression of protective bacteria Bacteroides. Disruption of genes important for the functioning of the immune system and the control of inflammation. Increased expression of ACE2 and other proteins that COVID-19 uses to enter cells.
Changes in neurotransmitter gene expression were also seen; This points to a possible connection between diet, gut and brain.
High-fat diets, particularly coconut oil, have been linked to increased stem cell activity in the colon, potentially increasing the risk of cancer in animals.
Negative effects were most pronounced with unmodified soybean oil; This suggests that linoleic acid may play a harmful role.
But while the widespread consumption of soybean oil and the shared DNA between humans and mice raise concerns, keep in mind that studies done on mice do not always translate directly to humans.
News materials cannot be equated with a doctor’s prescription. Consult an expert before making a decision.
Source: Ferra
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