This approach, detailed in a new study published in the journal Nature Communications, holds promise for increasing the recognition of cancer cells by the immune system.
The study marks the first successful use of an ultrasound device implanted in the skull to improve the delivery of doxorubicin and immune checkpoint-blocking antibodies to the human brain. This method temporarily opens the blood-brain barrier, allowing drugs to target glioblastoma more effectively. The combination therapy activates lymphocytes, the immune cells responsible for attacking cancer cells, and alters the tumor microenvironment to improve the immune response.
A study of four patients with advanced glioblastoma showed that this technique could significantly improve drug delivery and alter the immune structure of the tumor, making it more recognizable by the immune system. A new clinical trial has been initiated to further investigate the safety and effectiveness of this treatment.
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Source: Ferra
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