The study, led by Ruth Sacker and her team at Rockefeller University, used a new robotic system developed at the Center for Structural Biology in New York. This technology allowed for the rapid preparation of biological samples for cryoelectron microscopy and the identification of four different intermediate complexes in the early stages of transcription.
The main results of the study indicate structural changes in RNAP and its interaction with DNA strands that prevent double-helix reassociation and the formation of a stable transcription bubble.
This pioneering work not only resolves a long-standing debate, but also opens up new ways to study dynamic molecular interactions, the scientists report.
Source: Ferra
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