Traditional RNA synthesis methods, dating back to the 1980s, rely on toxic solvents and complex chemical reactions that produce significant amounts of waste in the environment. In contrast, the new enzymatic process developed at the Wyss Institute uses water and enzymes to achieve efficiency and purity comparable to industry standards without harmful byproducts.
The team, led by researchers including Dr. George Church, engineered enzymes from yeast to efficiently synthesize RNA and incorporated modifications critical to drug stability and efficacy directly into the synthesis process. This innovation provides greater design space and easier scalability, which is critical as global demand for RNA therapeutics continues to grow.
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Source: Ferra
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