Scientists have found that the HNF4A molecule suppresses the growth and aggressiveness of pancreatic cancer cells. In particular, HNF4A activity is significantly reduced in the early stages of the disease.
The pancreas is a gland in the digestive system that produces digestive juices and hormones such as insulin. Pancreatic cancer is a deadly disease that is extremely difficult to combat due to late diagnosis and resistance to treatment.
In the study, the researchers analyzed healthy tissue and tissue samples from pancreatic cancer patients to determine the mechanism by which tumors turn off HNF4A activity.
Scientists have discovered that certain changes occur in the HNF4A gene that turn it off. Low HNF4A activity has been shown to be associated with poor patient survival.
According to the scientist, understanding the mechanism by which HNF4A is deactivated could help develop new treatments, both alone and in combination.
Source: Ferra
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