The researchers used a method called “contextual conditioning” to train mice to remember a context that used high-calorie food. As a result, mice with a strong memory for the high-calorie food were unable to distinguish novel objects in their environment, demonstrating how a strong memory can inhibit the formation of new, flexible memories.
The study found that strong memories activate a fixed number of neurons, making it difficult to form new flexible memories. Strong memories, supported by synchronization of neuronal activity, interfere with the updating of new data, the scientists noted.
Source: Ferra
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