This mutation protects CD4 lymphocytes from virus penetration. It is particularly noteworthy that, unlike the previous three HIV treatments, the woman did not suffer from graft-versus-host disease.
The patient was also not on antiretroviral drugs for more than 18 months and no HIV RNA was found in his blood after transfusion. Even after stopping antiretroviral therapy.
Scientists say this case differs from previous HIV treatment cases for several reasons.
First, the patient was a woman of mixed heritage. Second, mutant cells were obtained from cord blood stored in a blood bank. Third, the patient did not suffer from transplant rejection by the body.
Experts noted that this method of treating HIV infection could become more suitable if more banks of cord blood are tested for detection of samples with CCR5-Δ32 mutations.
Source: Ferra
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