A study published in the journal Redox Biology found a reduction in mitochondrial proteins due to the increase in intracellular nitric oxide found in type 2 diabetes patients and animal models. The researchers wanted to determine whether changes in the complex subunits of the mitochondrial respiratory chain are associated with this mitochondrial dysfunction.
The study analyzed muscle samples from obese patients with type 2 diabetes and from obese patients in the early stages of diabetes, as well as samples from animal models of diabetes. This discovery could lead to earlier diagnosis and new treatments for type 2 diabetes.
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Source: Ferra
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