Spanish Agency for Medicines and Health Products (AEMPS) just published my new one drug safety report based on pharmacovigilance data for July and August.
These reports are prepared using notifications typically issued by health care providers who discover new symptoms in their patients associated with medications that are not on the list. technical sheet. This way, we can have a much more accurate idea of the precautions that should be taken when consuming them.
It is important to note that such reports do not call into question the safety of the drugs. If they end up in pharmacies, it is because they have undergone numerous clinical trials to test both their effectiveness and possible side effects, which usually should not be serious. But there are always exceptions. These are sometimes difficult to measure in such studies, so they need to be taken into account as the drug is distributed to the population. This is exactly what AEMPS just stated in list of 17 drugsof which 5 are especially famous among the population.
Drug safety may have many exceptions
Much of the new drug safety data revolves around special cases, such as pregnancy or the use of other medications. Others include indications such as a new dose that is just as effective but with fewer side effects. Each case is different, so it is important that they are all added to prospectsas will happen in the future.
Be careful with salicylic acid during pregnancy.
Salicylic acid can be prescribed in various forms, such as: ophthalmic or local. The latter, present in creams for relieving skin inflammation, can be dangerous during pregnancy. For this reason, new considerations have been added to the drug safety report.
It is not known exactly how it may affect the fetus in the first two trimesters, but there are signs of a possible risk. Therefore, it should be avoided to an acceptable extent and used in the minimum dose and for the shortest possible time.
On the other hand, the consequences of the third quarter are well known. May cause Cardiopulmonary and renal toxicity in the fetus. In addition, towards the end of pregnancy, cases of hemorrhage were detected in both the mother and the newborn. Therefore, at this stage of pregnancy it should not be used under any circumstances.
Be careful with Bisolvon.
He dextromethorphan with diphenhydraminebetter known as Bisolvon antitussive compositumit is not dangerous as such. However, new indications were added to the drug safety report due to the very large number of notifications affecting many drowsiness after consumption.
A review of the cases concluded that the doses stated in the package insert were too high. With less you can get the same results. Therefore, several changes were made. Let’s start with the fact that the drug comes in a child-proof bottle with a screw cap and is accompanied by dispensers. 1.24, 2.5 and 5 milliliters. This will make it easier to administer the new dose that is already listed on both the package insert and the technical information sheet.
Ibuprofen with codeine: the safety of these drugs has many exceptions
The combination of ibuprofen and codeine is used quite often to treat pain. The first connection is nonsteroidal anti-inflammatory drug and second a opioid. They can be found together in medicines such as Nurofen or Neobrufen with codeine.
Their combination is effective, but can have many side effects that cannot be ignored. This drug safety report notes that everything must start with the right Observation by a general practitioner check for suspicious symptoms and, above all, stop treatment as soon as possible. In addition, patients should be informed about the possibility of developing symptoms opioid use disorder because of codeine. If the treatment time is exceeded, codeine may become addictive and withdrawal symptoms will result in severe withdrawal symptoms.
Health care workers should monitor their patients to ensure that suspicious behavior. For example, by requesting an extension of the validity of the medicine in advance.
On the other hand, this combination of drugs may increase the likelihood of certain diseases. breathing disorders during sleepas well as apnea, so you will have to monitor them too. In addition, in hypersensitive patients, ibuprofen may cause Kounis syndromecharacterized by a narrowing of blood vessels that can lead to a heart attack if not detected in time. It should be noted that this is rare. But if the patient has previously shown hypersensitivity to ibuprofen, he should be warned not to take it again.
Finally, ibuprofen should not be taken in combination with gabapentinused to treat pain of neuropathic origin.
Avoid methylprednisolone if you have hyperthyroidism
methylprednisolone It is commonly used to treat inflammation in rheumatic diseases. In principle, this does not imply harmful effects beyond those stated. However, it has been observed that patients with hyperthyroidism or changes in potassium levels may cause thyrotoxic periodic paralysis. It is characterized by severe muscle weakness that eventually leads to paralysis. For this reason, hypertensive patients should avoid taking the drug and, if they have no choice, stop taking it at the slightest suspicion of muscle weakness.
New side effect of paracetamol
In fact, the likelihood that paracetamol causes metabolic acidosis with increased anion gap. This is a condition characterized by a significant drop in blood pH. It can be treated in many ways, but if not treated, it can be very dangerous.
This food safety report does not include the incidence of adverse events because it cannot be calculated. However, this does not seem to be very common. Still good to know Risk factors and symptoms. The former include female gender, liver or kidney disease, alcoholism, pregnancy, sepsis and especially the use of paracetamol for a very long period of time. As for the symptoms, if they are not associated with another disease, they are mainly deep and rapid breathing, confusion and lethargy.
First of all, if we are taking these drugs, we should not stop taking them. It is important to remember that they all have side effects, but most often there are no serious consequences. Information is power and this drug safety report should be taken into account, but its purpose is not to create panic. All this is unlikely and will happen in very specific cases. It’s nice to know them, but nothing more. In any case, if you have questions, consult your doctor or pharmacist.
Source: Hiper Textual
