He Colon cancer This has always been mainly associated with older people. Although it has a certain genetic component, also The environment is very affectedSo most cases were given Mutations have accumulated over the yearsNevertheless, in recent decades, a significant increase in diagnoses in Patients under 50 years oldThe field of this curious change was a mystery. In particular, because of the fact that, although this happens all over the world, it is distributed rather heterogeneous on the planet. Now, however, the international team of scientists led by Spanish Marcos Dias JayHe found an interesting explanation. According to your investigation, this may be due to Bacterial toxin I agreed in childhood.
The study, in fact, did not seek to analyze the influence of this bacterial toxin. These scientists, from California University of San Diego, Welcome Institute of Sanger of the United Kingdom and International Research in Wed Cancer ResearchThey analyzed the geographical distribution of these cases of colon cancer in young people. They wanted to know why the cast is so diverse between some countries and other countries. To do this, they resorted to bioinformatics and artificial intelligence, the specialty of Dias-geya. They analyzed computingly Genetic mutations patients with colorectal cancer and, VoilaThey found that mutations associated with a reduction in bacterial toxin in childhood were more than 3 times more common in patients under the age of 40 years. Everything that is compared to patients over 70 years old.
This not only changed their study. He also gave them a thread to try to prevent, diagnose and treat these cases of colon cancer in young people. Although, of course, also in the elder.
More and more young people with colon cancer
According to estimates, over the past 20 years, cases of colon cancer in people under 50 years old They doubled every decadeNevertheless, this cast was quite heterogeneous. For example, this is especially amazing in High income countries. This can lead to the fact that this is due to the lifestyle of its inhabitants. However, there are exceptions that attract attention. Spain is only one of them. And, although this is the fourth country with large cancer of the colon in people over 50, after Japan, Holland and DenmarkHe did not experience such a growth of young people.
This is one of the intriguing data that led to the authors of the study that has just been published in Nature To study the depth.
And how did they do it?
They analyzed Genom 981 patients with colorectal cancerOf the 11 different countries. The goal was to look for the most repeated mutations in order to determine the laws that in some ways can be associated with an increase in cases in young people and their heterogeneity around the world.
They saw that there was a particularly plentiful mutation. This is due to a toxin called ColibactinIt is produced by some strains Escherichia coliThe field since it is a bacterium that usually lives in the colon, it is not uncommon that there is this relationship. But there is something, which especially attracted the attention of these scientists: cases of cancer of the colon in young people were much higher when mutations began to develop Up to 10 years.
Now the origin of this bacterial toxin is determined
With these data, it is clear that children who earn infection with these stresses E.Coli Before it is 10 years old, they will have a higher risk of developing colon cancer up to 50 years. The reason is that bacterial toxin colibactin It has the ability to change DNA. But how does the infection are reduced with these concrete strains of bacteria?
These scientists also saw that there were genetic firms associated with bacterial toxin, which were the characteristics of the country. For example, they found this in Argentina, Brazil, Colombia, Russia and Thailand. This may indicate that, according to the country, the impact on colibactin is different. However, at the moment they could not determine how this exposition is given.
It will be necessary to continue the investigation. At least, we already have answers to this question, which was around our heads for so many years. What’s happened epidemic Cases of cancer of the colon in young people? Answering him, can help us find solutions. This is the most important.
Source: Hiper Textual
