Y chromosome: men live shorter than women

The Y chromosome is primarily responsible for the less lifespan of the Men than women. It should be noted that in 40% of 70-year-olds, the loss occurs during aging. The effect is the production of scarring on the heart, leading to fatal heart failure. This is confirmed by the American University of Virginia. However, Soichi Sano, who leads the research team, speculates that the negative consequences of the loss of the male chromosome can be resolved. The solution is in a pre-existing drug that fights scars on the body tissues.

We all know that women have two X chromosomes while men have an X and a Y. However, men begin to lose the Y with age and are at risk of dying younger or contracting diseases such as Alzheimer’s disease.

The DNA present in all our cells inevitably accumulates mutations with age. This includes the loss of the entire Y chromosome in part of the male cells. Understanding that the body is a mosaic of acquired mutations provides clues to age-related diseases and the aging process itself.

Kenneth Walsh, one of the authors of the study

The researchers used molecular scissors (Crispr) to study the disappearance of the Y chromosome in mice. diseases fromage. The cause seems to lie in the reactions of the immune system leading to a process called fibrosis. Research in England shows that Y’s disappearance is linked to heart problems and cardiac arrest.

In short, trying to eliminate the effects of the loss of the Y chromosome could help men live longer. The research team claims that the medicine promising is the pirfenidone, used for idiopathic pulmonary fibrosis. Also helpful in heart failure and chronic kidney disease. Always two diseases with scars on the tissues.