Experts from the Institute of Medical Science Hospital at the University of Tokyo have given new hope to patients with glioblastoma. It is a malignant tumor one of the most aggressive among those already brain. The research results show that it is possible to slow down the neoplasm by administering a virus. It is genetically modified directly in the tumor mass, increasing the survival chances for sick patients.
The study in 19 patients with glioblastoma was conducted in individuals with residual or recurrent disease. Scholars for slow down the spread of the tumor and giving it an input to receive a response from the immune system have modified a virus. This is the genetic modification of the virus known as cold sores, which is then tested on selected patients.
The six-dose treatment is nicknamed G47Δ. Although the available treatment choices are limited and life expectancy is short, this new treatment gives even more hope. Oncolytic viruses are aggressive viruses that kill cancer cells. The virus has been genetically modified to increase its relevance between cancer cells and stimulate a more effective response. Research results show that one year after treatment, 84% of patients were still alive. Overall, the median survival had reached 20 months. Finally, the study was approved by the Japanese authorities.
Patients who survived more than 3 years after G47∆ therapy had a smaller initial tumor size than those who survived less than 1 year. Therefore, early treatment may be warranted to achieve high efficacy and potentially achieve cure.
researchers
Source: Lega Nerd
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