The “Tired heart it is a heart condition in which the heart has difficulty pumping blood. It depends on genetic mutations of various molecular mechanisms. An international study has analyzed 800,000 heart cells from both healthy and sick patients.
These data provide potential therapeutic targets for future research and intervention options to improve and personalize treatments for cardiomyopathies and heart failure.
researchers
Our findings have enormous potential to rethink the way we treat heart failure and underline the importance of understanding the root causes and the mutations that lead to changes that can alter heart functioning.
Christine E. Seidman of Hms, Research Coordinator
The study focused on analyzing cell samples from 18 healthy subjects and 61 heart patients. Scientists have realized that the cell samples from the sick contain a small number cardiomyocytes. These are cells of the heart. On the other hand, the cells of the immune system and those of the blood vessels increase, while those of the connective tissue do not increase.
The development of the disease can be caused by: different genetic mutations that trigger a variety of molecular mechanisms. It depends on most cells in the immune system, which are related to blood vessels and increased activity of connective tissue cells. Basically, the study maps every type of cell in the body. Help develop more and more personalized therapies to reduce the number of heart failure patients who need a heart transplant.
Source: Lega Nerd
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