What we don’t think about when transplanting organs is that they can live an amazingly long life if we add in the time they spent with the donor and the time they survived with the recipient. In the case of the liver, it has been observed that in some cases this additional age may over 100 years. This is the conclusion of a recently presented investigation in 2022 American College of Surgeons (ACS) Clinical Congress Scientific Forum. It contains factors that converge in what its authors dubbed centurion organs.
In general, a number of factors coincide both on the part of the donor and on the part of the recipient, which facilitate the ability of the organ survive much longer than the donor might have survived under different circumstances. And knowing this is very important, as it can help you choose the best liver for transplant. After all, the longer they survive, the better the quality of life of the recipient.
Is it true that the latest methods of immunosuppression they significantly increase the lifetime of organs for transplantation. However, the liver of the centurion may give us interesting data to further increase this time. Let’s see what these scientists are from Southwestern UT Medical School.
Keys to Centurion Liver Transplant
To conduct their study, these scientists analyzed From 1990 to 2022, 253,406 livers were transplanted.. Of these, 24 can be attributed to centurion liver.
the best donors
The first thing that catches the eye is that centurion liver donors had an average of 87.5 years. On the one hand, this is logical, since they traveled with a donor for most of that century, which makes them centurions. However, this is also curious, since one could assume that they poor quality organs. In fact, older people are often considered less suitable. Of course, even though they were older, the donors were especially healthy, as they had diabetes and infections much lower than that of non-centurion livers. In addition, they also play a key role transaminaseswhich were much lower among centurion liver donors.
Transaminases are very important proteins in the metabolism of cells of various organs, including the liver. However, if they are elevated, they may be indicates health problemsTherefore, it is not surprising that livers with lower levels survive longer after transplantation.
As regards recipients, it has been observed that those who received the centurion organ MELD scores much lower. It is a measure of survival for people with liver disease and is measured by analyzing three parameters: bilirubin, serum creatinine, and international normalized prothrombin time ratio (INR). The lower the index, the better the forecast.
Therefore, if both donors and recipients are optimal, much longer organ survival can be achieved. However, it is important to note that this is long-term information. There was no difference in graft rejection rates at 12 months. liver of a centurion or non-centurion. Later, the benefits of matching a healthy donor with a recipient who, despite needing an organ, had a better prognosis were seen. Not surprising, really. What is surprising is that while it is very difficult for a person to be over 100 years old, their individual organs can go through a century with relative ease.
Source: Hiper Textual