Magazine, Thursday (1st) World AIDS Day Science published the results of a clinical trial that, although small, showed positive results for an HIV vaccine. The immunizer, which is still in its infancy, has managed to provoke people. an immune response component in 97% of participants.
This reaction occurred because the experimental vaccine produced so-called “broadly neutralizing antibodies” (bNAbs) of HIV in the human body. While these glycoproteins can neutralize various strains of the AIDS virus, they are also unique in that they specifically target the conserved epitopes of the virus. Epitopes are fragments of antigens with physicochemical properties. facilitate the recognition of antibodies🇧🇷
This means that bNAbs can recognize a wide variety of HIV subtypes that are essential for generating immunity. because the HIV virus is constantly mutating. And that’s what happened: The results demonstrated proof of clinical concept for the strategy of priming the immune response, in which the vaccine dose presents antigens (stimulating antibody production) for the first time.
training the immune system
From a population of 48 study participants, 36 received the candidate vaccine and 35 of these showed B-cell activation, “antibody factories”. In order for these cells to form their defense mechanisms, they must produce a lineage of the immune system called the “germinal”.
This happens through a process known as forced evolution or gradual maturation, which is enabled by the multiple vaccination program. According to William Schief, Professor of Immunology and Microbiology at Scripps Research, one of the study’s authors, the idea is to “train” the immune system to recognize multiple HIV variants.
The professor says that despite the promising results observed, there is no guarantee that the vaccine will be fully effective. After a while, Phase 2 tests will begin, and as vaccine applications take place, the molecules will get closer to the real HIV until the resulting antibodies can bind to different types of viruses. “A whole new way of how to make a vaccine”Schief concludes.
ARTICLE 🇧🇷 Science – DOI: 10.1126/science.add6502.
Source: Tec Mundo
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