The study, conducted in mice, aimed to recruit T regulatory cells that suppress inflammation in the colon by increasing the expression of the GPR15 receptor. When mice were fed extra tryptophan, the number of T regulatory cells in colon tissue doubled and colitis symptoms were significantly reduced.
The results reveal the possibility of a noninvasive and dietary approach to the long-term treatment of colitis. Although the research results indicate a preventive effect, scientists warn that tryptophan may not be effective during active flares of the disease.
The research team is currently planning to conduct clinical studies to confirm the findings in humans.
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Source: Ferra
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