Scientists at the Buck Institute have determined that the OXR1 gene is critical for longevity and healthy aging in the brains of fruit flies and human cells. This gene, found in neurons, plays an important role in the retromer, the protein recycling system necessary for neuron health.

OXR1 protects cells from oxidative damage, a key factor in aging and neurodegenerative diseases. Its importance is clearly evident in both humans and mice; its loss causes serious neurological problems, and its gain increases survival in ALS models.

The research team carefully demonstrated how OXR1, activated by food restriction, maintains retromer function and protects neurons. This slows down the aging of the brain and increases life expectancy.

The consequences for humans? Findings suggest that strategies such as intermittent fasting or calorie restriction may increase OXR1 levels, which could potentially provide therapeutic benefits for age-related neurodegeneration.

Researchers aim to identify compounds that increase OXR1 levels during aging, which could potentially lead to new interventions in brain health.

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Source: Ferra

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