This discovery, published in the journal Nature, sheds light on the development of cancer and neurodegenerative diseases and offers new treatment options.
Genome is the genetic material found in cells. Its stability is necessary for information to be correctly divided and transmitted to new generations of cells.
Researchers in the United Kingdom screened 1,000 strains of genetically modified mice to find genes that affect genomic stability.
145 genes were associated with micronucleus formation, signs of genome instability, and DNA damage.
Gene DSCC1 was particularly important: Knocking it out increased micronucleus formation fivefold; This is reminiscent of cohesinopathies, which are rare genetic diseases in humans.
Inhibiting the SIRT1 protein partially restored genomic stability, paving the way for new treatments.
This discovery is an important step in understanding and treating diseases associated with genomic instability.
Source: Ferra
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