Previous studies have linked changes in the gut microbiome to a variety of diseases, including type 2 diabetes and obesity. This study examined how these microbes may affect cardiovascular health. The team analyzed data from more than 1,400 participants in the Framingham Heart Study, combining genetic information about gut bacteria with metabolite levels (chemicals produced during metabolism). They discovered a specific bacteria called Oscillibacter, which is commonly found in the intestines and appears to lower cholesterol levels in people with high cholesterol levels.
Further studies showed how Oscillibacter potentially breaks down cholesterol. Researchers grew bacteria in the laboratory and identified specific enzymes responsible for converting cholesterol into byproducts that are then eliminated from the body. The study also identified another type of gut bacteria, Eubacterium coprostanoligenes, that may work with Oscillibacter to lower cholesterol. This finding highlights the importance of investigating the interactions of different microbial communities to influence health.
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Source: Ferra
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