Previous studies have suggested that Parkinson’s disease may begin in the olfactory center of the brain or in the gut. A new study brings these ideas together, suggesting that inhaled toxins such as pesticides contribute to the brain-first pattern. Conversely, toxins entering the body from contaminated food or water may trigger the body pattern first.
The study highlighted certain environmental toxins such as dry cleaning chemicals, weed killer, air pollution (car exhaust) as potential culprits.
These toxins are thought to trigger the formation of alpha-synuclein, a protein that accumulates in the brain and causes the symptoms of Parkinson’s disease. The study’s authors suggest that where toxins enter may affect the form of Parkinson’s disease.
The authors believe these models may help scientists link certain environmental exposures to specific forms of Parkinson’s disease. They also suggest that these models can be applied to other brain diseases.
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Source: Ferra
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