In a new study, scientists from the German Cancer Research Center (DKFZ) and the University of Tübingen revealed how intermittent fasting affects non-alcoholic fatty liver disease.
Researchers fed mice a Western-style diet rich in fat and sugar for 32 weeks. This led them to develop non-alcoholic fatty liver disease. Later, some of the animals continued on this diet, while the other part switched to a 5:2 intermittent fasting regime.
It turned out that the group that practiced intermittent fasting did not gain weight and also showed fewer symptoms of liver disease. The mice also had lower levels of biomarkers indicating liver damage. Scientists concluded that 5:2 intermittent fasting contributed to the animals’ resistance to the development of non-alcoholic fatty liver disease.
The proteins responsible for the protective function of starvation turned out to be PPAR-alpha and PCK1.
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Source: Ferra
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