Using a combination of activity-based protein profiling (ABPP) techniques, the team identified which proteins and specific regions on them bind to chemical compounds. This data could help develop more effective anticancer drugs.

According to the scientists, one method gives a general idea of ​​​​the interactions, while the second shows the exact locations of these interactions. The researchers used stereoprobes, chemical compounds that bind irreversibly to proteins, especially cysteine, which plays an important role in the structure of cancer cell proteins.

This dual strategy allows for more precise targeting of protein targets, which could lead to the development of new treatments to fight cancer.

Source: Ferra

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