The study, published Oct. 4 in the journal Science Advances, shows the detrimental health effects if paternal mitochondrial DNA is not removed early in development.
Using roundworms (C. elegans) as a model, researchers found that delays in the paternal mitochondrial removal (PME) process lead to decreased production of ATP, which is important for cellular energy, ultimately leading to cognitive impairment, behavioral changes, and reproductive problems. in adult worms.
This discovery not only deepens our understanding of mitochondrial diseases, which affect approximately 1 in 5,000 people, but also suggests that taking vitamin K2 supplements before birth may be a preventative measure for families with a history of such diseases.
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Source: Ferra
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