Rapamycin. It may improve the ability of cells to engage in autophagy, an anti-aging “spring cleaning.” The effectiveness of this drug was demonstrated in 20-month-old mice. This corresponds to approximately 60 human years. The drug increased life expectancy in rodents by 20%. Unfortunately, no one has yet conducted a proper randomized trial in older people. This still awaits us.
Medicines in the medicine cabinet. These include diabetes medications (canagliflozin, dapagliflozin, empagliflozin, metformin, and acarbose), bisphosphonate medications (usually taken to reduce bone loss), and weight loss medications (Wegovy, Ozempic). For example, canagliflozin has been proven to increase life expectancy in male mice by 14%.
Senolytics. Results of a study published in 2018 showed that the combination of dasatinib and quercetin helped destroy senescent cells in old mice and extend their disease-free lives. They didn’t get cancer or heart disease, and they felt better while exercising. Dozens of subsequent studies showed similar results. 20 companies are currently trying to commercialize both drugs and many other “senolytic” treatments.
gene activation. Preliminary results from a study showed that a mouse’s lifespan could be increased by 25% by activating special “Yamanaka genes” later in life. If Altos Laboratories succeeds in developing drugs for humans based on this work, Professor Shinya Yamanaka will become the first person in history to win a second Nobel Prize for the same discovery.
drug mixture. Rapamycin and the antidiabetic drug acarbose extended the lifespan of mice the most. On average, male mice lived about 40% longer when given this combination, while female mice lived 30% longer.
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Source: Ferra
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