The model uses the evolutionary and structural data of the virus to estimate future changes on the surface. Therefore, thanks to Eve-VAX, scientists were able to design proteins that cause immune answers similar to those observed in real viruses. This opens new opportunities to create vaccines that do not exist but can protect against possible options for the virus.
The main purpose of Eve-VAX is to develop “lifelong” vaccines that do not require constant updates. This is important because modern vaccines often do not have time to adapt to new viruses, which reduces their activity. For example, to create a vaccine from the Covid-19, scientists have to predict how the virus will change within a year, which may not overlap with reality.
The researchers designed new versions of the SARS-COV-2 spike protein, which the virus uses to infect the cells, using Eve-VAX. These proteins were tested in the laboratory and showed the ability to cause a real immune response.
Source: Ferra
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