“Our study shows that brain damage may contribute to an increased risk of developing brain cancer later in life,” the scientists said. During the experiment, young adult mice with traumatic brain injury were injected with a substance that permanently stains the brain cells of astrocytes red and turns off the function of a gene called p53. The control group was treated in the same way, but the p53 gene was left untouched.
It turned out that after the injury, the astrocytes changed shape. Scientists have suggested that mutations in certain genes are associated with brain inflammation caused by acute trauma. This increases the risk of cancer.
Scientists then began looking for evidence to support their hypotheses in humans. They looked at the electronic medical records of more than 20,000 people diagnosed with head trauma, comparing the incidence of brain cancer with a control group. It turned out that patients who had a head injury were almost four times more likely to develop brain cancer later in life than those who had not been injured.
Source: Ferra
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