The researchers focused their attention on a protein complex called AMPK, which acts as a cellular energy sensor. For example, if AMPK detects low glucose levels, it can signal the body to use fat for energy.
However, fat intake blocks the activity of this complex, causing metabolic disorders. In the new study, the team took a protein called SAPS3, which is closely related to AMPK and its mechanisms, and extracted it from the mouse genome. The rodents were then fed a diet containing 45% fat.
Consequently, deletion of SAPS3 released AMPK in these mice, allowing them to maintain a normal energy balance despite consuming large amounts of fat. “We were surprised that they maintained their normal weight, avoided obesity and developed diabetes,” the scientists said.
Source: Ferra
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