The sensors are capable of detecting a variety of cancer proteins and can also help determine the type of tumor and its response to treatment. This could make diagnosis more accessible to patients everywhere.
The nanoparticles are designed to release short DNA sequences when they enter the tumor, and these DNA “barcodes” are excreted in the urine.
Researchers can analyze barcodes to identify the hallmarks of a particular patient’s tumor. The test can be done with a paper strip, similar to the Covid home test.
In tests on mice, the researchers showed that the sensors could detect the activity of five different enzymes expressed in tumors.
They also showed that their approach was able to distinguish at least 46 different DNA barcodes in a single sample using a microfluidic sample analyzer.
The researchers suggest that because human tumors are so diverse, more than five barcodes may be needed for use in humans.
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Source: Ferra
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