The research team analyzed blood samples from 333 newborns in Sweden. The analysis revealed 24 million specific chemical tags associated with methylation. Statistical analysis helped identify specific tags for each cell type.
Next, the scientists compared the data with information about genes that were active in 595 brain samples of humans after they died. Among these people were both people with schizophrenia and healthy people.
In addition, the researchers compared blood methylation data from 2970 adults, including patients with schizophrenia and healthy controls.
As a result, the experts found that certain differences in methylation that children are born with indicate an increased risk of developing schizophrenia.
Although this disease is mainly of genetic origin, scientists have been able to show that environmental factors also influence its development. These factors cause chemical changes in DNA that result in abnormal activation of certain genes due to methylation.
Source: Ferra
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