Researchers from the Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences have created and patented a drug that can be used in the treatment of arterial hypertension, coronary heart disease, rhythm and cardiac conduction disorders.
Arterial hypertension (presence of high blood pressure), which affects 20-30% of the world’s population, is one of the main risk factors for the development of coronary heart disease, chronic heart failure, myocardial infarction and stroke.
The researchers’ proposed pharmacological composition is based on β-blockers, α2-adrenergic receptor agonists, and a nitric oxide (NO) donor. Russian biologists have found that β-blockade and α2-adrenergic receptor increase the effect of each other, while reducing the concentration of calcium ions in the blood. This allows them to reduce their effective dose and thus reduce side effects.
In addition, experiments on heart tissues have shown that the combined use of an α2-adrenergic agonist and an NO donor contributes to an additional reduction in calcium ion currents and reduces the load on the heart.
Source: Ferra
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