Our brain is the control center of absolutely everything that we do, including the act There isIt is in it that we decide in it when we began to eat, and when we stop doing it. This generates this irritating Feeling hunger When he determines that we must eat and make us something Feels saturated When we have enough. The processes through which all this is very interested in scientists, because in some cases they can be hacked to prevent or treat obesity. You know enough. First of all, the hormones involved in the process are known. However, it has not yet been known which neurons collect the information of all involved components and give us the final order To stop eating.
It was intuitive for a long time Encephalum trunkThe field is a region that Transfers the cerebral cortex and cerebellum and controls the same vital as Breathing or heart rate. It is also known that it contains neurons that regulate actions such as Look, hears, go and talk. Of course, there is also. But it was for everything that regulates that it was so difficult to find concrete neurons that regulate satiety.
The authors of the study, which has just been published in Cell used a technique known as Molecular profit with spatial resolutionwhich allows Individually analyze cells They are part of the set. For example, it is used in oncology to analyze tumor cells. In this case, he finally helped with those neurons that can be so useful for the treatment of obesity in the future that perhaps this is not so far.
Light to turn off light neurons
As soon as they found neurons in the brain trunk, whose function was unknown, it was analyzed with the help Mouse experimentThe field for this, they resorted to Optogenetics This is a method that allows you to use light to turn on and off certain neurons in genetically modified mice. This is very useful for Smell the brainSince, if the type of neuron is turned off, and we stop fulfilling any activity, we already know that this type of neuron is involved in it.
When these neurons are lit, mice ate shorter rations. In addition, the greater the intensity of the light, He stopped eating faster. On the other hand, if neurons came out, rodents ate without control.
It doesn’t matter that the level of hormones was suitable. It is clear that these neurons have the last word. In fact, it was also evident that hormones that increase appetite They tend to shut up these neuronsBye GLP-1 Agonists They activate them. LPG-1 is a molecule that promotes satiety, slows down the emptying of the stomach and helps to release insulin to control the level of glucose in the blood. Agonist drugs are those who imitate their function in the body. There are many of them, but the most famous is the famous Ovorpik.
Therefore, these recently discovered neurons are those that really tell us that we stop eating. Hormones, how Grelinwhich contributes to hunger, or leptin, This contributes to satiety, it is produced when they detect the presence or absence of food in the digestive system, but the waterfall of events begins with them, which will not be carried out without these neurons.
How can this help obesity?
Logically, before trying to handle people through this discovery, it will be necessary to check if it is extrapolated Nevertheless, the researchers are optimistic, since they indicate that there are few differences between the barrel of the brain of mice and a person.
If it is proved that we have the same neurons with the same function, they can look for ways to partially turn off for the treatment of obesity. In any case, it should be clear that Obesity is a non -pharmacyThe field is not all people with obesity for a lot. The regulation of satiety can be useful in some, but in others not. Therefore, even if this conclusion gave rise to a revolutionary appeal, we could not consider this a unique measure against obesity. We will strengthen the fact that for weight loss you just need to eat less, and the truth is that this is a much more difficult problem.
Source: Hiper Textual
