A Crisis of bacteria resistant to antibiotics, crisis This is becoming more and more serious, so the need to look for new bactericides. Substances with an antimicrobial effect were found in the most unexpected places, from the microbiota of cats to the blood of the pond. However, much more is necessary, so scientists continue to investigate the potential of new substances. Recently a team of scientists from North -Eastern University From Boston, Massachusetts, he wanted to look for options in samples of the Earth. Various members of the research group brought samples from different places, but the laboratory technique was the location of the perfect sample.
These scientists mostly wanted to put bacteria to fight with each other. It is known that there are bacteria that can be very harmful to others. Often the struggle is carried out through Issue toxinTherefore, they thought that it would be interesting to find a toxin of some kind of harmless bacteria for people who could kill these bacteria resistant to antibiotics that hurt us. Since the Earth is a place with a huge variety of bacterial populations, they decided to grow samples of bacteria discovered on Earth carrying laboratory workers. Then they kept them for a whole year, and after this time they proved their effectiveness to fight bacteria Escherichia coli.
Contact Paenibacillus They had the opportunity to fight this. In addition, they noticed that this was due to the release of a substance called LariocidineProfiles and, even better, they confirmed that this substance has the ability to attack bacteria resistant to antibiotics, as their Modus Operandi This is very different from what is used by these drugs.
The inevitable danger of bacteria resistant to antibiotics
According to a study published in Lancet In 2024, bacteria resistant to antibiotics threaten to put an end to life 208 million people In the next 25 years. Many infections that have been considered soft for their mild treatment in recent decades can again cause serious diseases, as before the discovery of penicillin.
He improper use that we do from antibiotics, Using them when they are not needed, or excessive use in livestock, among other habits, they lead to the fact that this is becoming an increasingly common problem. The great quiet pandemic, which we did not pay attention.
Little by little, since the death of people increased due to infections with bacteria resistant to antibiotics, we knew. A terrible and terrible antibiogram indicates that the analyzed bacteria are resistant to all antibiotics is already a reality. In addition, if we do nothing to solve it, it will be more and more frequent. By logic, in addition to increasing the awareness of the population, in order to better use antibiotics, it is recommended that scientists look for scientists Alternatives to these drugsThe questionnaire indicated in the 2024 report, which in 2023 was a total of 97 joint compounds for antibacterial drugs at the clinical development stage. There is a lot of research, but more is needed. That is why it is so important that the laboratory technician found in his garden.
Treasure in the garden
The authors of the study published in Nature They found that Lariocidine is special from their method of attacking bacteria. While antibiotics usually attack directly on the cell wall of bacteria, preventing their survival or blocking their reproduction or nutrition, laryocidine focuses on their Protein factories.
And this is that bacteria, like our own cells, have inside the organelles called ribosomes, which are responsible for the construction of proteins specified in the instructions of their genetic material. As soon as the information is ready for translation, it joins ribosomes. A Transfer RNA. This is a type of RNA that carries amino acids that act as blocks for building proteins. These proteins will be necessary for cell survival. In this case, bacteria.
The information read by a ribosoma is in the form of the RNKSENGER. This consists of a long combination of four different types of letters: A, u, g and C. They belong to adenin, uraceil, guanin and cytosine. These are the grounds for nitrogen, which differentiate some nucleotides from others, nucleotides are blocks that make up DNA and RNA. But let’s not look at it. We are going to stay with a ribosoma, the long combination of these 4 letters: a, u, g and C.
The importance of the genetic code
The amino acids that we have seen are blocks that make up proteins have 20 different types. Each of them corresponds to 3 of these letters. For example, the UCA combination refers to Serin and CCG to the valve. This connection between amino acids and each triplet is what is known as Genetic code As the Messenger RNA passes through the ribosoma, the portable RNA is hooked to the chain, which will become an amino acid corresponding to the three letters that you read.
What does Lariocidine do? Attack both ribosomes and RNA transmission. This does not prevent protein formation, but interrupts the correct functioning of the protein factory and its amino acid supplier. Therefore, they are built erroneous proteins This is currently becoming toxic for bacteria.
Bacteria resistant to antibiotics did not learn how to evade this mechanism, because no antibiotic acts. It was evident that Lariocidine slowed down the growth of a number of common pathogenic bacteria, including many Multiplying strainsIn addition, in cultures with human cells there was no toxicity. And something else is better: in the treatment of mice resistant to antibiotics with this substance, they survived. Instead, the UN treatment died in less than 28 hours.
We will have to continue the investigation, this is true. Nevertheless, it seems that the laboratory technique of the garden hid the great candidate as a treatment for bacteria resistant to antibiotics. It is a treasure.
Source: Hiper Textual
