Recently, in a study published in the scientific journal Journal of AutoimmunityResearchers at the University of Missouri in the United States identified some specific mutations. monkey flower🇧🇷 The results bring a warning: these variations can help create a stronger, smarter version that can reduce the effect of antiviral drugs, and vaccines🇧🇷
The researchers analyzed the DNA sequences. More than 200 varieties of monkey flower and so he realized that mutations occur at critical points and even affect the effectiveness of vaccines and antibodies. Fortunately, the findings could help develop new drugs and vaccines that better respond to the virus.
According to Kamlendra Singh, professor at the University of Missouri School of Veterinary Medicine, the structure of monkeypox is similar to that of the vaccinia virus. The pair allowed the scientists to build a 3D model of the virus, showing where the mutations are and what the differences are that make the virus so contagious.
“By doing a temporal analysis, we were able to see how the virus has evolved over time, and a key finding was that the virus is now accumulating mutations, especially where drugs and vaccine antibodies should bind. So the virus becomes smarter, able to avoid being targeted by drugs or antibodies from our body’s immune response, and continues to spread to more people,” says one of the co-authors, Shrikesh Sachdev.
monkey flower
Either way, scientists are still trying to understand how the virus has evolved in recent years. One hypothesis is that HIV and Herpes drugs, also used against smallpox, may have helped the virus become smarter and more contagious, while another hypothesis is that it uses proteins in the human body to reinforce itself.
“These factors are certainly contributing to the increase in the contagiousness of the virus. This work is important because the first step to solving a problem is to identify exactly where the problem is occurring, and it’s a team effort,” Singh said.
Source: Tec Mundo
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